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    The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Il presente articolo sul Sildenafil riporta le informazioni che è possibile reperire sul foglietto illustrativo del prodotto commerciale o sul sito della casa produttrice e dagli studi medici in bibliografia, non intende pubblicizzarne l'uso o promuoverlo in nessun modo, si ricorda di avere sempre la supervisione di un medico e di attenersi alle sue indicazioni, altresì le informazioni potrebbero essere non aggiornate per cui si consiglia di recarsi dal proprio medico o farmacista per ulteriori informazioni, inoltre si raccomanda di non fare acquisti su internet per la pericolosità di presunte farmacie e soprattutto senza un medico. Avere Possiamo dire come informazione primaria che Sildenafil agisce sulle strutture vascolari del pene, i cosiddetti "corpi cavernosi", favorendo l'afflusso di sangue all'interno di essi e di conseguenza permettendo l'erezione. La compressa di Sildenafil va assunta possibilmente lontana dal pasto; dopo circa 50 minuti, una sufficiente concentrazione del farmaco Sildenafil raggiunge i corpi cavernosi ed in presenza di eccitazione l'erezione risulterà facilitata; l'efficacia ha una durata che può andare dalle 4 alle 6 ore. Il farmaco Sildenafil viene metabolizzato a livello epatico da due citocromi: il citocromo 3A4 ed il citocromo 2C9. Il principale metabolita ottenuto è l’N-demetil sildenafil il quale è ancora farmacologicamente attivo (è in grado di inibire le 5PDE con una potenza, rispetto al sildenafil, del 50). Il rilassamento dei muscoli lisci dei corpi cavernosi dovuto al Sildenafil è mediato dall’ossido di azoto (NO) che attiva l’enzima guanilato ciclasi che catalizza la trasformazione della guanosina trifosfato o GTP in guanosina monofosfato ciclico o c GMP che stimola il rilasciamento muscolare. Ecco alcuni possibili comuni effetti collaterali di Sildenafil : mal di testa, stomaco agitato, infezioni del tratto urinario, sensibilità aumentata ai colori verde e rosso, diarrea, altri problemi, etc.

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