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    The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website. The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website. Sildenafil is used in the treatment of Erectile Dysfunction . Erectile dysfunction is the inability to achieve or maintain an erection long enough to perform sexual intercourse. Headache, flushing, respiratory tract infection, angina pectoris, AV block, migraine, syncope, tachycardia, postural hypotension, MI, cerebral thrombosis, cardiac arrest, paraesthesia, tremor, depression, herpes simplex, skin ulcer, oesophagitis, abnormal LFT, rectal haemorrhage, hypoglycaemic reaction, arthritis, deafness, retinal vascular disease, photosensitivity, accidental fall. Metabolism: Metabolised in the liver mainly by CYP3A4 and CYP2C9. Inhibitors of CYP3A4 such as cimetidine and erythromycin are likely to reduce sildenafil clearance. Potentially Fatal: May potentiate hypotensive effects of of organic nitrates and nicorandil. Patients concurrently or intermittently using organic nitrates in any form. Excretion: Excreted as metabolites mainly in the faeces. CYP3A4 inducers such as rifampicin may decrease the plasma concentrations of sildenafil. Sildenafil inhibits phosphodiesterase type-5 (PDE5) which is responsible for c GMP degradation in the corpus cavernosum. Caution when used in patients with anatomical deformation of penis or conditions that may predispose them to priapism (e.g. Mild, transient, dose-related impairment of colour discrimination (blue/green) may occur. Inhibition of PDE5 increases c GMP levels in the corpus cavernosum which results in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Hepatic or severe renal impairment, bleeding disorders, active peptic ulceration, hypotension, recent history of stroke, MI, arrhythmias, unstable angina, heart failure or retinal disorders.

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