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  7. Ter_n New Member

    Wyeth Pharmaceuticals is heavily promoting Effexor XR for the treatment of depression and Generalized Anxiety Disorder (GAD), and the gist of the promotion is that Effexor XR is more powerful at producing remission than the SSRIs. Even if it is believable, how should this influence our prescribing decisions? As practitioners, we have all been bombarded by the Effexor promotional literature, with slogans such as: “THE GOAL IS REMISSION OF SYMPTOMS” and “LET’S GET IT RIGHT THE FIRST TIME.” These are hardly news flashes to psychiatrists, and the implication that we don’t already try our darndest to get our patients all the way well is mildly insulting. Of course, we all know where Wyeth is coming from here. They are trying to convince us to think in terms of “remission” (Ham-D depression scale 7 or less) rather than “response” (Ham-D 50% improved) because Effexor XR claims to be better than the SSRIs at bringing about remission, but not at producing response. Let’s look at the basis for Wyeth’s claim, which is the now famous study published in the British Journal of Psychiatry in 2001 by Thase et al (1) showing that Effexor’s remission rates were 45% (vs. The study had excellent methodology, comprising a pooled analysis of all the data the company had collected comparing Effexor with Prozac, Paxil, and Luvox. By psychiatric research standards, the numbers were huge: 851 patients in the Effexor XR group, 748 in the SSRI group (Prozac, Paxil, and Luvox), and 446 in the placebo group. The doses of comparator SSRIs were robust enough to mirror what we actually use in clinical practice, and treatment duration was reasonable, between 6 and 8 weeks. Best Antidepressant for Anxiety - Consumer Reports buy zithromax suspension Effexor XR vs. Zoloft for GAD - Anxiety - MedHelp Compare Effexor vs Zoloft - Comprehensive Analysis by Treato
     
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