Carole, Just curious, did you try the generic (hydroquix...)or brand name Plaquenil? When I started Plaquenil, my GI system was in an uproar. I couldn't tolerate the generic, but the brand name has a coating for the stomach. Turmeric and plaquenil Plaquenil lupus en espanol Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell. I "know" I need some meds, but cannot tolerate Plaquenil. Wondering if anyone has come across something "natural" that mimics it. Thanks & LIGHT*****carole - Hi, Carole. When I started Plaquenil, my GI system was in an uproar. But it usually was anyway. I didn't realize, until I saw Dr. In some cases, they may not be available in every strength or form as the brand-name drug. Wallace's book and found the stats, plus my rheumie telling me much the same, that many people with lupus (something like 40% or more) "present" with GI problems. Meaning long enough to start to sort out whether your problems were mainly from the disease or from the med? Substitute for hydroxychloroquine Hydroxychloroquine Side-effects, uses, time to work, Common and Rare Side Effects for Hydroxychloroquine Oral Stopping plaquenil suddenlyPlaquenil effect on spermPlaquenil maculopathy fundus autofluorescenceOcular testing for plaquenilCan i take metformin with hydrochloroquine I have taken Plaquinel/hydroxychloroquine at a low dose as maintenance for my SLE for over 20 years. No side effects. No problems. Until I went on Medicare and they don't want to pay for it. They want me to try cheaper alternatives before they will pay for hydroxychloroquine. I can take it but I would have to pay a high price for it. Alternatives to Hydroxychloroquine - Lupus - Inspire. Natural" alternative to Plaquenil. - HealthBoards. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Because the action of Plaq isn't really understood in SjS, and it's a unique classification of drug in treating AIs, there really isn't a substitute for it, but there are other classes of drugs, also called DMARDS disease modifying anti-rheumatic drugs that are also used. Glenn Frey's death, tied in part to rheumatoid arthritis medications he was taking, is a 'wake-up call' about the dangers of powerful drugs used to treat the condition, a top doc says. It should push arthritis patients and their doctors to seek out safer available alternatives. arthritis, alternative, remedies, rheumatoid, glenn, frey. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.