Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. I have lupus am allergic to plaquenil substitute Chloroquine glioblastoma OUTLINE This is a dose-escalation study of hydroxychloroquine. Patients receive hydroxychloroquine orally PO twice daily BID on days -14 to 84 and aldesleukin intravenously IV every 8 hours on days 1-5 and 15-19. Treatment repeats every 84 days for up to 3 courses in the absence of disease progression or unacceptable toxicity. Researches Say Hydroxychloroquine Can Help Treat Cancer March 14, 2012 By Leave a Comment Researchers say a drug commonly used to treat malaria and rheumatoid arthritis has also proved effective in treating some aggressive cancers. This phase I trial studies the sides effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes, or other places in the body and cannot be removed by surgery. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine clinical trial cancer Hydroxychloroquine in Previously Treated Patients With., Researches Say Hydroxychloroquine Can Help Treat Cancer. Plaquenil drug manufacturer Clinical trials are research studies that involve people. The clinical trials on this list are studying Hydroxychloroquine. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. Clinical Trials Using Hydroxychloroquine - National. Trametinib and Hydroxychloroquine in Treating Patients with.. Phase I/II Study of Hydroxychloroquine With Itraconazole With.. Along the lines of the Trial Watch series published on a monthly basis in OncoImmunology,35-38 here we summarize the dual role of autophagy in oncogenesis and tumor progression and discuss recent clinical trials investigating the use of chloroquine CQ, hydroxychloroquine HCQ in cancer patients. Description This phase I trial studies the sides effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes, or other places in the body and cannot be removed by surgery. Hydroxychloroquine is FDA approved to treat malaria and other conditions, but has also not been approved for these cancer types. Preliminary results have shown that this combination of drugs is effective at killing cancer cells and shrinking tumors in several KRAS-mutated cancers in animals.