She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Chloroquine lysosomal accumualtion Chloroquine malaria dna binding theory Patient information leaflet on hydroxychloroquine Jan 01, 2011 SriniVas Sadda, MD, is associate professor of ophthalmology at the Keck School of Medicine of the University of Southern California and the Doheny Eye is Director of the Medical Retina Unit, Ophthalmic Imaging Unit, Retinal Transplantation Laboratory and Digital Image Reading Center. Nov 01, 2015 Hydroxychloroquine Maculopathy An Update on Screening and Diagnosis A brief guide for imaging SHIRI SHULMAN, MD. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. Etinopathy were monitored for 6 months to 82 months after HCQ cessation with multimodal imaging including spectral domain optical coherence tomography and fundus autofluorescence imaging at 488 nm standard and 787 nm near-infrared autofluorescence. Tests of visual function including visual acuity, Humphrey visual field testing, and multifocal electroretinography mfERG were performed. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Retinal deposits plaquenil infared imaging TOXIC EFFECTS OF HYDROXYCHLOROQUINE ON THE CHOROID. RETINA, Retinal Physician - Hydroxychloroquine Maculopathy An Update. Hydroxychloroquine dosage aaoChloroquin quininePlaquenil screening eye examPlaquenil macular toxicity Retinal!toxicity.and!it!has!largely!replaced!chloroquine!as!a!treatment!ofinflammatory!disease. Unfortunately.the!retinal!damage!from!these!medications. Plaquenil toxicity-eye rounds edited FINAL WARD. LONGITUDINAL CHANGES IN EYES WITH HYDROXYCHLOROQUINE RETINAL.. Miscellaneous - Retina Image Bank. Apr 30 2013 by Theodore Leng, MD, MS Fundus autofluorescence from a 44-year-old woman with bilateral plaquenil toxicity. There is an area of hyperautofluorescence that corresponds to areas of outer retinal damage. Conversely, in both normal adults and patients, we found many thickened structures that were undetect- able in visible wavelength light. To improve imaging of sub-retinal structures, we used infrared light, which passed readily into and out of the deeper fundus layers, with little visual consequence or pupil constriction Wyszecki & Stiles, 1982b. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1.