This type of malaria medication consists of two different drugs, one called chloroquine phosphate and one called proguanil hydrochloride, that are taken as two separate tablets but are packaged together. The two drugs are taken in combination to be more effective against malaria and as a form of malaria treatment, by inhibiting the reproduction of the parasites responsible for causing malaria. Plaquenil stomach upset Plaquenil therapy Malaria Prophylaxis. 250 mg/100 mg 1 tablet PO daily, beginning 1-2 days before travel to malaria-endemic area and continued until 7 days after return ; Treatment. 1 g/400 mg 4 tablets PO daily for 3 days; Dosing considerations. In event of vomiting within 1 hour of dose, repeat dose Dec 02, 2000 The risk of developing malaria for travellers to East Africa who take no chemoprophylaxis is about 12% per month and chloroquine-proguanil has prophylactic effectiveness of 72%. 7 If the average duration of travel is 25 weeks, the expected rate of malaria in travellers taking prophylaxis would be 02% per month with chloroquine-proguanil and 0035% per month with a drug that has 95% effectiveness. In The Travel and Tropical Medicine Manual Fifth Edition, 2017. Author recommendations For travelers to areas with known or potential chloroquine-resistent malaria with a predominance of Plasmodium falciparum or Plasmodium vivax, clinicians should prescribe any of the following malaria preventive drugs mefloquin, doxycycline, chloroquine-proguanil, or atovaquone-proguanil. In some countries, chloroquine proguanil medication requires a prescription, and in other places it is available without a prescription, but it is recommended to consult a doctor before taking any malaria medication. Both these drugs can have serious side effects, especially when taken together, including itching, skin rash, stomach pain, bloody stool, and hair loss. Chloroquine-proguanil malaria prophylaxis Chloroquine & Proguanil Anti-Malarial Tablets, Atovaquone-proguanil versus chloroquine-proguanil for malaria. Plaquenil and hyperpigmentation sjogren'sPuckering of tongue plaquenil Jun 29, 2012 Blood Stage Prophylaxis In Vivax Malaria. Blood stage prophylaxis is the most common type of prophylaxis in use. Chloroquine, was the first drug in this group to be extensively used. It was introduced in the early 1950’s for the prevention of both falciparum and vivax malaria. Prophylaxis of Malaria - PubMed Central PMC. Chloroquine Plus Proguanil - an overview ScienceDirect.. Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health.. Prevention of Malaria. Malarone is indicated for the prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. Treatment of Malaria. Malarone is indicated for the treatment of acute, uncomplicated P. falciparum malaria. Malarone has been shown to be effective in regions where the drugs chloroquine, halofantrine, mefloquine, and amodiaquine may have unacceptable failure rates, presumably due to drug resistance. Chloroquine Exceptions to legal category Can be sold to the public provided it is licensed and labelled for the prophylaxis of malaria. Considerations when choosing a drug for malaria prophylaxis Recommendations for drugs to prevent malaria differ by country of travel and can be found in Malaria Information by Country. Recommended drugs for each country are listed in alphabetical order and have comparable efficacy in that country.