A 65-year-old Caucasian woman presented with insidious onset of symmetric bilateral lower and upper limb weakness, which progressed slowly over the last 3 years. The pattern of weakness was mainly proximal, with some minimal to mild distal weakness evolving in recent months. She also developed some tingling and numbness in her toes followed by fingertips over the last year. Benefits of plaquenil for lupus Plaquenil for adenomyosis Hydroxychloroquine dose Dose related myopathy Daily dosages of chloroquine of 500 mg given for 1 year or longer Drug features At extracellular pH drugs are poorly ionized & penetrate membranes Acid pH in lysosome Cationic region interacts with polar materials Long half-lives 3.5 to 12 days Clinical Weakness, Proximal Distal Pathology Hydroxychloroquine-induced myopathy with striking muscle pathology. The recognition of this toxic myo-pathy and discontinuation of hydroxychloroquine resulted in dramatic improvement of the patient’s strength and function. CASE REPORT A 51-year-old Caucasian man had mantle cell lym-phoma diagnosed in 1995. He was initially treated A woman with systemic lupus erythematosus developed severe myopathy after a septicemic episode, and her treatment before admission was hydroxychloroquine sulfate and prednisolone. This was attributed to pericarditis based on workup at an outside facility. She unintentionally lost 20 pounds since the onset of weakness. Approximately 3 years ago, the patient had an episode of chest pain lasting several days. Hydroxychloroquine myopathy pathology Chloroquine neuromyotoxicity. Clinical and pathologic., Hydroxychloroquine Causes Severe Vacuolar Myopathy in a. Withdrawal from plaquenilCan hydroxychloroquine help osteoarthritisDoxycycline and plaquenil interactionsCode for plaquenil eye examFinasteride vs plaquenil This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine-Induced Myopathy Request PDF. Hydroxychloroquine-induced restrictive cardiomyopathy.. Acid phosphatase is not a single enzyme but rather a group of enzymes that hydrolyze and release phosphate group from different substrates By definition, they function best in an acidic environment and are normally localized in the lysosomes Mol Pathol 2002; In muscle biopsies, the acid phosphatase stain is an enzyme histochemical stain that relies on endogenous acid phosphatase. Oct 15, 2012 Hydroxychloroquine HCQ is a 4-aminoquinoline which differs from chloroquine CQ in the addition of a hydroxyl group. Initially used as antimalarials, both drugs have now become mainstays in the management of rheumatic diseases principally systemic lupus erythematosus SLE and rheumatoid arthritis RA. Mar 01, 2011 New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy a report of 2. Cardiac pathology of systemic lupus erythematosus. J Clin.