Chloroquine oral pigmentation

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    Chloroquine oral pigmentation


    Pigmentation can be either normal or abnormal discoloration of oral mucous membrane. The purpose of this review mainly focuses on the main oral pigmented lesions, in order to help the clinicians establish a better approach towards the patients with pigmented oral lesions and to provide thorough knowledge regarding such lesions for patient reassurance, early definitive diagnosis and prompt treatment.

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    PIGMENTED LESIONS OF ORAL MUCOSA Oral and Perioral pigmentation may be physiologic or pathologic in origin. Assume variety of discolorations, including brown,blue, grey & black. These color changes often occur due to deposition,production or increased accumulation of various endogenous or exogenous pigmented substances. Given the history of long-term chloroquine use, the top clinical working diagnosis was drug-induced oral pigmentation caused by chloroquine phosphate. To confirm this, and rule out the possibility of melanoma, a surgical evaluation was requested and the patient then underwent an incisional biopsy Fig. 2. Use of antimalarials ie, quinacrine, chloroquine, hydroxychloroquine HCQ can induce tissue pigmentation in a variety of organs, including skin, joint tissue, trachea, and cartilage in the nose and ears.

    Pigmented lesions affecting the skin were not included in our review. Relevant data concerning oral pigmented lesions, clinical features and the possibility of malignant transformation of such lesions were reviewed thoroughly from pubmed literature published in English.

    Chloroquine oral pigmentation

    Chloroquine Uses, Side Effects & Warnings -, Palate Hyperpigmentation Caused by Prolonged Use of the Anti-Malarial.

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  3. Oct 01, 2018 Chloroquine phosphate tablets, Chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble inwater.

    • Chloroquine - FDA prescribing information, side effects and uses.
    • Hydroxychloroquine-Induced Pigmentation in Patients With..
    • Oral Pigmentation - SlideShare.

    Chloroquine is rapidly and almost completely absorbed from the bowel following oral administration. Peak plasma concentrations of chloroquine are reached within 4–12 hours, but it takes 4–6 weeks for plasma concentrations to stabilise; therefore, it will take 2–3 months to see a therapeutic effect. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. The pigmentation resolved in two patients following chloroquine withdrawal despite being substituted by hydroxychloroquine. Hence, hydroxychloroquine may score over chloroquine not only with reference to ocular toxicity 9, but also with reference to cutaneous toxic-ity, for its long term use in patients suffering from con-

     
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    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Lupus Medicines Hydroxychloroquine - Brigham and Women's Hospital The New Lupus Drug That Could Replace Plaquenil - Lupus Lyfe
     
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    The Risk of Retinal Toxicity with Plaquenil Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy.

    Eye screening for patients taking hydroxychloroquine Plaquenil
     
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    Aquarium Medications Part 2 Antibiotic & Antimicrobial. Folic acid is a large molecule and is unable to enter bacterial cells, so the bacteria must synthesize the compound intracellularly. Animal cells are unable to synthesize folic acid and it must be provided in the diet. For this reason sulfa drugs are not toxic to animal cells.

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