Chloroquine resistant falciparum malaria

Discussion in 'Hydroxychloroquine 200 Mg Tab' started by SovBes, 24-Feb-2020.

  1. Niza Moderator

    Chloroquine resistant falciparum malaria


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Travelers who reject the advice to take prophylaxis, who choose a suboptimal drug regimen such as chloroquine in an area with chloroquine-resistant P. falciparum, or who require a less-than-optimal drug regimen for medical reasons, are at increased risk for acquiring malaria and then needing prompt treatment while overseas. Since the first reports of chloroquine-resistant falciparum malaria in southeast Asia and South America almost half a century ago, drug-resistant malaria has posed a major problem in malaria control. By the late 1980s, resistance to sulfadoxine-pyrimethamine and to mefloquine was also prevalent on the Thai-Cambodian and Thai-Myanmar Thai-Burmese borders, rendering them established multidrug. Three-hundred and two specimens were successfully analysed. No chloroquine-resistant genotypes were detected. The study found the disappearance of chloroquine-resistant malaria after the removal of chloroquine drug pressure. Chloroquine may have a role for malaria prevention or treatment in Zambia and throughout the region in the future.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine resistant falciparum malaria

    Drug resistance in malaria - World Health Organization, Epidemiology of drug-resistant malaria - The Lancet.

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  7. Resistance in malaria. Since the first documentation of P. falciparum chloroquine resistance in the 1950s, resistant strains have appeared throughout East and West Africa, Southeast Asia, and South America. The effectiveness of chloroquine against P. falciparum has declined as resistant strains of the parasite evolved. They effectively neutralize the drug via a mechanism that drains chloroquine away from the digestive vacuole.

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    Chloroquine resistance is widespread. Chloroquine should not be used for treatment of P. falciparum infections from areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed. Patients infected with a resistant strains of plasmodia should be treated with another antimalarial drug. Chloroquine CQ, was the most frequently used first-line therapy for uncomplicated P. falciparum malaria from the 1940s through to the 2000s due to its high efficacy, safety and low cost 2. Resistance to CQ was first identified on the Thai-Cambodian border in the late 1950s, concomitantly in South America. FALCIPARUM malaria resistant to prophylactic and therapeutic doses of chloroquine phosphate is widespread in Southeast Asia, especially in Vietnam, and occurs in South America, especially in Colombia and Brazil. This development is truly calamitous, since what was almost an ideal drug is becoming of.

     
  8. Awar Moderator

    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Researchers in the laboratory have tested tumors from patients with pancreatic cancer and have discovered that they have certain pathways inside the cells that promote growth and survival of the tumor. Phase II and Pharmacodynamic Study of Autophagy Inhibition. Targeting Autophagy in Cancer Update on Clinical Trials. Adding Hydroxychloroquine to Chemo Fails to Improve OS in.
     
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