While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I started the hydroxychloroquine medication a week ago and within the first day or two noticed a big difference in my pain and fatigue with major improvement SLE. Mg per kg body wt hydroxychloroquine dosage Pots dysautonomia plaquenil Side effects are all GI related for the first few weeks to a month, but are no longer a problem after your body adjusts to the med. I also grew my hair back quickly & fully within a year of starting Plaquenil. It is FANTASTIC for fatigue & pain. I am sick much less often than prior to starting Plaquenil hydroxychloroquine is the generic name." All since then I've been tested and diagnosed. Today my rheumy decided to go ahead and prescribe plaquenil. My main issues are joint, muscle and tendon pain/inflammation,As well as fatigue. Besides my possible heart and lung involvement My doc said plaquenil will help with the pain and inflammation. Will it help with the fatigue? I just want to do something to help. Does icing the painful joints help? Heat? I just feel so helpless. The dr doesn't want to increase the pain meds and until the Plaquenil starts to do its thing which I understand can take a while I feel like we're stuck and she has no choice but to suffer through it. While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. Plaquenil (hydroxychloroquine) is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Plaquenil help with fatigue Plaquenil for fatigue and pain DailyStrength, Does plaquenil help with fatigue. DailyStrength Hydroxychloroquine phosphate Treating the Pain and Fatigue. If the patient has widespread pain and fatigue in Sjogren's, there is a significant chance that they also have lupus, rheumatoid arthritis RA or fibromyalgia. The diagnosis and treatment of lupus and RA are fairly straightforward. Why There's More to Sjogren's Syndrome The Dr. Oz Show. Nausea from Plaquenil, etc" Lupus Community - Support Group. Chronic Fatigue From RA 6 Ways to Fight Back Everyday Health. Acupunture, yoga, massage and physical therapy might help as well. Changing your diet to eliminate gluten, increase omega 3's, eliminate processed foods might also help with fatigue and joint pains. Lastly, a drug that is related to plaquenil called quinacrine may be helpful to take. This has lower incidence of retinal toxicity than plaquenil. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. This will help reduce swelling, pain, and. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.