It will look at – in detail – quinine and quinine-related drugs. In a previous article, we briefly described malaria and artemisinin as a lead compound for new antimalarials. Hydroxychloroquine for crest syndrome Hydroxychloroquine sulphate and pregnancy Hydroxychloroquine weigh In this review, we have attempted to present an overview of recent progress and applications of different heterocyclic scaffolds as potential antimalarials to underscore the way for the development of new antimalarial agents. We have briefly summarized a variety of heterocyclic scaffolds employed for the development of various antimalarial drugs. The term heterocyclic comes from Hetero = different, and Cyclic = ring. Heterocyclic molecules have atoms other than carbon in their ring. You’ll commonly see oxygen, nitrogen, and even sulfur in heterocyclic aromatic compounds. Heterocyclic molecules can also participate in aromaticity. This positive result eventually led in 1925 to the synthesis of pamaquine. The next event was the attachment of the basic side chain of pamaquine to several different heterocyclic ring systems, leading to the synthesis of the acridine derivative quinacrine having an extra benzene ring and thus an acridine nucleus when compared with chloroquine. Understanding the chemistry of these compounds also, as it happens, makes it much easier to comprehend the pharmacology and therapeutic management of malaria itself. We now turn our attention to the other antimalarial drugs. Heterocyclic ring present in chloroquine Supplementary data Orienting the Heterocyclic Periphery., Aromaticity Tutorial for Cyclic, Charged and Heterocyclic. Hydroxychloroquine rheumatoid arthritis dosePlaquenil lftsHydroxychloroquine allergic reactionHydroxychloroquine plaquenil reviewsPlaquenil otc We now turn our attention to the other antimalarial drugs. Understanding the chemistry of these compounds also, as it happens, makes it much easier to comprehend the pharmacology and therapeutic management of malaria itself. We’ll begin our analysis of the medicinal chemistry of antimalarial drugs by looking at quinine and its related compounds. Medicinal Chemistry of Antimalarial Drugs. Chloroquine analogues in drug discovery new directions of.. Heterocyclic compound chemistry Britannica. Heterocyclic amines, also sometimes referred to as HCAs, are chemical compounds containing at least one heterocyclic ring, which by definition has atoms of at least two different elements, as well as at least one amine nitrogen-containing group. Typically it is a nitrogen atom of an amine group that also makes the ring heterocyclic e.g. pyridine, though compounds exist in which this is. Heterocyclic Compounds. Compounds classified as heterocyclic probably constitute the largest and most varied family of organic compounds. After all, every carbocyclic compound, regardless of structure and functionality, may in principle be converted into a collection of heterocyclic analogs by replacing one or more of the ring carbon atoms with a different element. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.