Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil alopecia areata Hydroxychloroquine pigmentation Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Methotrexate is used to treat some forms of cancer and some autoimmune diseases. PPIs which include omeprazole, esomeprazole, pantoprazole, lansoprazole and rabeprazole are used for the symptomatic relief of gastric reflux-like symptoms. The potential interaction with methotrexate relates to all PPIs. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Prilosec methotrexate prednisone plaquenil interactions Study Shows Methotrexate and Prednisone Combination., Rheumatoid Arthritis Treatment Options Johns Hopkins. Plaquenil zonDoes plaquenil stop joint destruction in ra There are no listed interactions between Aleve and Plaquenil. If you plan to take both Aleve and Plaquenil, it would be best to consult with a doctor or pharmacist dosage instructions and possible. Why take plaquenil for lupus - Answers. Interaction Methotrexate and Proton Pump Inhibitors. Methotrexate and plaquenil -. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Plaquenil is very effective for the symptoms of achiness and fatigue. However, there might be a price to pay in terms of retinal toxicity especially after taking it for as long as you have. Given that the alopecia had developed while you were on the plaquenil, it's not clear that going back on it will help that symptom much. Methotrexate MTX is a nonbiological disease-modifying antirheumatic drug that has shown both a good control of clinical disease and a good safety. Usually drug-drug interactions DDIs represent the most limiting factor during the clinical management of any disease, in particular when several drugs are coadministered to treat the same disease.