Pharmacokinetics of chloroquine in rats

Discussion in 'Cheap Chloroquine' started by softdiagess, 06-Mar-2020.

  1. Raphael Moderator

    Pharmacokinetics of chloroquine in rats


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Data for allometric scaling were obtained from 6 animal studies mice, rats, rabbits, monkeys. Pharmacokinetics of chloroquine in Thais plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria. The pharmacokinetics of chloroquine do not differ to a clinically important extent between black and white patients 11, 69, 79. The average melanin content of a black person is estimated to be 1 g and for a white person is estimated to be 250 mg. Experientia 38, 1326-1327. Adelusi S. A. and Salako L. A. 19a Kinetics of the distribution and elimination of chloroquine in the rat. Gen. Pharmac. 13, 433-437. Adelusi S. A. and Salako L. A. 19b The effect of protein-energy malnutrition on the absorption, distribution and elimination of chloroquine in the rat. Gen. Pharmac. 13, 505-509.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Pharmacokinetics of chloroquine in rats

    Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait., Pharmacology of Chloroquine and Hydroxychloroquine Springer.

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  3. Pharmacokinetics of the Antimalarial Drug, AQ-13, in Rats and Cynomolgus Macaques. The pharmacokinetics of chloroquine after single oral 600 mg and intravenous 2 mg kg-1 doses were studied.

    • Pharmacokinetics of the Antimalarial Drug, AQ-13, in Rats..
    • Adsorption, distribution and elimination of chloroquine in..
    • Pharmacokinetics and Toxicity in Rats and Monkeys of..

    INTRODUCTION. Chloroquine CQ was introduced 50 years ago as an alternative to quinine 25, 70became the drug of choice for both prophylaxis and treatment of malaria, but resistance has caused a decline in the contemporary clinical use of chloroquine 25, 35, 40, 70, 72. Chloroquine pharmacokinetics in tissues of pyrogen treated rats and implications for chloroquine related pruritus. Osifo NG. The concentrations of chloroquine in the tissues and plasma of control and pyrogen treated Long Island rats were serially determined over 16 days. Significant alterations of pharmacokinetic parameters, a delayed. The single oral dose pharmacokinetics of chloroquine was studied alone and after coadministration with phytomedicines NIPRID/92/001/1-1 AM-1, Niprisan®, and Nifadin® in rats. Plasma chloroquine concentrations were measured using High performance liquid chromatography HPLC method developed earlier in our laboratory. The data were fitted into a WinNonlin standard non-compartmental.

     
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