Additionally, another exception occurred while executing the custom error page for the first exception. Download PDF Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine (Plaquenil). Malaria tablets chloroquine Fishman chloroquine phosphate Hydroxychloroquine plaquenil and chloroquine have an affinity for pigmented ocular structures and binds to melanin in the RPE; With prolonged exposure, plaquenil accumulates in the retina and disrupts lysosomal function in the retinal pigment epithelium cells Lysosomal dysfunction creates abnormal retinal metabolism Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Download PDF. Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine Plaquenil. 1 “Rick” Fraunfelder, MD, director of the Registry and associate professor of ophthalmology at Oregon Health & Science University in Portland. There are hundreds of drugs with potential retinal toxicity—so many that the National Registry of Drug-Induced Ocular Side Effects doesn’t stratify them by incidence or effect, said Frederick W. Retinal deposits plaquenil Medications that can Affect the Eye or Visual System, Chloroquine and Hydroxychloroquine Toxicity Practice. Plaquenil for thromboembolismPlaquenil for erythema nodosumCheap aralen malariaChloroquine and diazepam A number of drugs may cause adverse retinal complications. A common one is hydroxychloroquine Plaquenil, Sanofi-Aventis See “Tackle Toxicity,” https//bit.ly/2OOWrLS. Here, I discuss drug-induced conditions of the retina. CRYSTALLINE RETINOPATHY. Refractile crystalline deposits in the retina may indicate drug toxicity. Optometric Management - Retina. Rx Side Effects New Plaquenil Guidelines and More - American.. Retinal Screening for Hydroxychloroquine Plaquenil Toxicity.. Rarely plaquenil can have toxic effects on the retina. If the daily dose of plaquenil exceeds the body's ability to clear out the medication then it can leave deposits in different tissues of the body, particularly the underlay beneath the central vision part of the retina macula. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative.