These disorders are usually inherited, meaning they are caused by abnormalities in genes passed from parents to children. When a person has a porphyria, cells fail to change body chemicals called porphyrins and porphyrin precursors into heme, the substance that gives blood its red color. Plaquenil side effects pregnancy Chloroquine metabolism Has been used in treatment of porphyria cutanea tarda†. 114 116 117 See Patients with Psoriasis or Porphyria under Cautions. Has been effective in some cases when used in the treatment of polymorphous light eruptions†. Hydroxychloroquine Sulfate Dosage and Administration Administration Oral Administration. Administer orally. 109 Mar 12, 2020 Singal AK, Kormos-Hallberg C, Lee C, Sadagoparamanujam VM, Grady JJ, Freeman DH Jr, et al. Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea. There are two current treatments for PCT. The first and more common treatment is repeated phlebotomies removing blood, but that also includes the potential disadvantages of discomfort, inconvenience and expense. The second options is a low-dose treatment with medications that are normally used to treat malaria-- hydroxychloroquine or chloroquine. Bone marrow is the soft, spongelike tissue inside the bones; it makes stem cells that develop into one of the three types of blood cells—red blood cells, white blood cells, and platelets. The body makes heme mainly in the bone marrow and liver. Low-dose hydroxychloroquine in treatment of porphyria Low-Dose Hydroxychloroquine is as Effective as Phlebotomy in., Which medications should be avoided by patients with porphyria? Who manufactures sandoz plaquenilPlaquenil patient informationName brand plaquenil There were no significant side effects of either treatment. CONCLUSIONS Hydroxychloroquine, 100 mg twice weekly, is as effective and safe as phlebotomy in patients with PCT, although noninferiority was not established. Given these results, higher-dose regimens of hydroxychloroquine, which have more side effects, do not seem justified. Low-dose hydroxychloroquine is as effective as phlebotomy in treatment.. Hydroxychloroquine vs. phlebotomy for porphyria cutanea tarda. Low-dose hydroxychloroquine is as effective as phlebotomy.. Therapeutic phlebotomy is the removal of about a pint of blood from a vein in the arm. A technician performs the procedure at a blood donation center, such as a hospital, clinic, or bloodmobile. A patient does not require anesthesia. Another treatment approach is low-dose hydroxychloroquine tablets to reduce porphyrins in the liver. Cumulative probability of time to remission of 17 patients with porphyria cutanea tarda randomized to treatment by phlebotomy n=7, black line or low-dose hydroxychloroquine n=10, gray line. The median time to remission was similar with hydroxychloroquine. Porphyria cutanea tarda PCT is a term encompassing a group of acquired and familial disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase UROD is deficient. Approximately 80% of all cases of porphyria cutanea tarda are acquired; 20% are familial, although the ratio may vary among different geographic regi.