Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Prednisone and plaquenil during pregnancy Moa of chloroquine in malaria Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram I was diagnosed almost 2yrs ago with Lupus, SLE & subacute subcutaneous. The plaquenil made me lose my hair immediately. When it came back in most of it came in white which I read that the medicine can bleach your hair. Then last year I noticed areas on my legs that are brown or maybe it's that my skin has been bleached in areas and is very white. Skin rash; Serious Side Effects of Plaquenil. If you are taking Plaquenil long-term, such as for an autoimmune condition, your doctor should regularly check you for potential serious side effects. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil side effects skin discoloration Skin Discoloration and Plaquenil - Arthritis Information, Plaquenil & skin discoloration - Plaquenil burning eyesPlaquenil energy level Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Will you have Nail discoloration with Plaquenil - eHealthMe. I believe this has been mentioned a while back, but thought I'd ask again who has gotten small brown spots on their skin after sun exposure? I've been on Plaquenil about 2 months, and it has helped my knee/back pain, which is wonderful! I also had read that th Hydroxychloroquine side effects. Hydroxychloroquine side effects may vary greatly from very mild side effects that go away with time to severe side effects like eye damage, ear damage, or heart problems. Some side effects may be experienced as the body adjusts to hydroxychloroquine but may diminish as the body becomes used to the drug. Skin discoloration is a possible side effect of plaquenil. It can also cause discoloration of your fingernails. Usually it is not serious, but you should let your doctor know about it as soon as you can."