Here we described a non-diabetic patient with RA who developed hypoglycaemia under hydroxychloroquine (HCQ) treatment. We also discussed the possible mechanisms of hypoglycaemia due to HCQ. Hydroxychloroquine and skin hardening What does plaquenil do for you Coming off plaquenil Chloroquine diphosphate dmem How to use Plaquenil. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Taking hydroxychloroquine with these drugs could cause hypoglycemia low blood sugar. Your doctor may need to reduce your dosage of insulin or the other diabetes drugs. Examples of other diabetes. Patients treated with PLAQUENIL should be warned about the risk of hypoglycemia and the associated clinical signs and symptoms. Patients presenting with clinical symptoms suggestive of hypoglycemia during treatment with PLAQUENIL should have their blood glucose checked and treatment reviewed as necessary. PRECAUTIONS He had a history of pain and swelling in his fingers, wrists, elbows and shoulders for 3 yrs. A 62-yr-old man was admitted to our hospital with symmetric polyarthritis and morning stiffness for more than 2 h in 2005. Plaquenil hypoglycemia DailyMed - PLAQUENIL- hydroxychloroquine sulfate tablet, Hydroxychloroquine Side Effects, Dosage, Uses, and More How does plaquenil work on the immune systemDoes chloroquine decrease potassium levelsIs there a generic form of plaquenilPlaquenil toxicity vf Hypoglycemia Plaquenil has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with or without antidiabetic medications see DRUG INTERACTIONS and ADVERSE REACTIONS. Patients treated with Plaquenil should be warned about the risk of hypoglycemia and the associated clinical signs and symptoms. Plaquenil - FDA prescribing information, side effects and uses. Plaquenil Concordia Pharmaceuticals Inc. FDA Package Insert. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. I can't take Plaquenil during the day due to its side effects so taking it at dinner lets me sleep away the side effects like headache. Plaquenil makes me feel like my stomach is turning inside out and I swear I can feel it heating up the blood in my veins. I felt hypoglycemic when I took it without food or with just light carbs. So back to the Sjogren's World Forums participant this person noticed that after beginning to take Plaquenil, it became more difficult to keep her diabetes in control occasionally her blood sugar became too low and she had symptoms of hypoglycemia feeling very anxious, tremor, feeling suddenly very hungry, perspiring heavily, and feeling faint. Several others chimed in, many of whom were not diabetic, and said that they noticed the same thing. Plaquenil and hypoglycemia? Has anyone experienced this side effect? Newly diagnosed with early RA, rheumatologist started me on 200mg Plaquenil 1x/day for first two weeks, going up to 2x/day after two weeks.