Ophthalmologic complication of hydroxychloroquine

Discussion in 'Canadian Pharmacy' started by perplexity, 14-Mar-2020.

  1. upsarin Well-Known Member

    Ophthalmologic complication of hydroxychloroquine


    Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention.

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    Low blood cell counts have happened with hydroxychloroquine. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak. A 45-year-old black female presented with no ocular or visual complaints. Her ocular history was unremarkable. However, her medical history was significant for a recent diagnosis of lupus. Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil hydroxychloroquine, Sanofi-Aventis therapy. Elderly patients and those with preexisting retinal and macular disease are believed to be at higher risk since they may be more prone to developing ophthalmic complications. 13. Currently, there is no treatment for hydroxychloroquine-induced retinopathy. Discontinuation can help stop progression, but damage may not be reversible.

    Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine.

    Ophthalmologic complication of hydroxychloroquine

    Ophthalmologic safety of long-term hydroxychloroquine sulfate., New Plaquenil Guidelines

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  4. What is Hydroxychloroquine, and What Does It Do? According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from complications.

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    The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication. However, these findings do not explain the clinical pigmentary. Hydroxychloroquine has unique immunomodulatory properties and an attractive adverse effect profile. Over the past 10 years, research has led to significant updates in clinical recommendations concerning the optimal use of hydroxychloroquine and monitoring of patients taking it. This review summarizes the current literature regarding the ocular complications of hydroxychloroquine. Hydroxychloroquine has been used since the 1950s for the treatment of various rheumatic and dermatologic diseases. Hydroxychloroquine can cause ocular toxicity, with the most serious being an irreversible retinopathy. At the present time, no "gold standard" exists for identification of the.

     
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