Trametinib hydroxychloroquine pancreatic cancer

Discussion in 'Canadian Pharmacies' started by dmMrak, 08-Mar-2020.

  1. eJik-mod Guest

    Trametinib hydroxychloroquine pancreatic cancer

    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    Apr 18, 2016 Pancreatic ductal adenocarcinoma PDAC is among the deadliest cancers with a dismal 7% 5-year survival rate and is projected to become the second leading cause of cancer-related deaths by 2020. KRAS is mutated in 95% of PDACs and is a well-validated. A recent study shows that the combination of MEK inhibitor trametinib and hydroxychloroquine led to a striking disease response in a patient with pancreatic cancer. O'Hara et al. reported the results from a phase II, single arm study in patients with metastatic colon cancer treated with hydroxychloroquine in combination with standard first-line chemotherapy mFOLFOX6 29. The findings presented today focused on advanced pancreatic cancer patients who enrolled in XCELSIOR and were treated with a MEK inhibitor, trametinib, in combination with an autophagy inhibitor, hydroxychloroquine, a generic medication approved by the U. S. Food and Drug Administration FDA for treatment of malaria, as part of their clinical cancer care.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Trametinib hydroxychloroquine pancreatic cancer

    A randomised, double-blind, placebo-controlled trial of., Phase Ib/II study of hydroxychloroquine in combination.

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  6. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

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    Hydroxychloroquine in Previously Treated Patients With Metastatic Pancreatic Cancer Hydroxychloroquine is approved for the treatment of non-cancerous illnesses such as rheumatoid arthritis and systemic lupus erythematous. Researchers in the laboratory have tested tumors from patients with pancreatic cancer and have discovered that they have certain pathways inside the cells that promote growth and survival of the tumor. Hydroxychloroquine HCQ is an old FDA-approved drug used to treat malaria, and it inhibits autophagy. Based on this discovery and the drug’s availability, HCQ was tested in clinical trials for pancreatic cancer, but it did not have an impact when used alone. However, once the patient began receiving 2 mg of trametinib plus 1200 mg of hydroxychloroquine daily, his CA19-9 levels declined precipitously by ~ 95% over the ensuing 2 months indicative of response. There are also a number of clinical trials for pancreatic cancer, that may be worth considering. Good luck!

  7. YarM Guest

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Buy Cheap Plaquenil Online Hydroxychloroquine Reviews Everyday Health Hydroxychloroquine Price Comparison Uses, Dosage, Form.
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  9. Heck User

    Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine comes as a tablet to take by mouth. For prevention of malaria in adults, two tablets are usually taken once a week on exactly the same day of each week. The first dose is taken 1 to 2 weeks before traveling to an area where malaria is common, and then doses are continued for 8 weeks after exposure.

    Hydroxychloroquine Side Effects, Dosage, Uses, and More