Fluorescein angiography and hydroxychloroquine maculopathy screening

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  1. mamonic Moderator

    Fluorescein angiography and hydroxychloroquine maculopathy screening


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Fluorescein angiography FA Optical coherence tomography OCT Fundus autofluorescence; Multifocal electroretinograms mf ERG. Early detection of any maculopathy is critical to prevent central visual loss. The Retina Group of New York provides all of these testing modalities and is the only center on Long Island with mf ERG. Treatment Fluorescein angiography showed the atrophic window defect characteristic of hydroxychloroquine maculopathy. On June 10, 1999 her Humphrey 10-2 visual field showed an annular scotoma bilaterally. Follow up on December 7, 1999 showed stable 20/50 best-corrected visual acuity and unchanged Humphrey 10-2 visual fields Figure 6, Figure 7. Nov 14, 1998 Editor —The articles cited by May et al confirm that the incidence of hydroxychloroquine retinopathy resulting in permanent or progressive visual loss is extremely low. If the drug was introduced today it would be difficult to justify the initiation of a screening programme.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Fluorescein angiography and hydroxychloroquine maculopathy screening

    Hydroxychloroquine and chloroquine retinopathy screening., Hydroxychloroquine and chloroquine retinopathy screening for drug.

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  3. Hydroxychloroquine is a commonly used medication for rheumatoid arthritis, systemic lupus erythematosus, discoid lupus, Sjögren syndrome, juvenile idiopathic arthritis, other mixed connective tissue autoimmune conditions, non-small cell lung cancer, and graft-versus-host disease GVHD, to name a few.

    • Determine risk for hydroxychloroquine retinal toxicity Optometry Times.
    • Screening for hydroxychloroquine retinopathy Screening..
    • Hydroxychloroquine Maculopathy An Update on Screening and..

    Hydroxychloroquine should undergo periodic and comprehensive eye examinations. The aim of the Fig. The bull’s eye pattern of depigmentation associated with chloroquine maculopathy is evident on fundus photographs and highlighted by fluorescein angiography photographs of the a right eye and b left eye; and Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up Paul Salu. The PPP hydroxychloroquine retinopathy screening exams include a comprehensive ophthalmologic evaluation with central visual field assessment by either Amsler grid or Humphrey Visual Field HVF 10-2 perimetry Zeiss, Dublin, CA.

     
  4. Fr1sT Well-Known Member

    , also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.) is possible, and would indicate that the drug is highly distributed into tissue. Chloroquine phosphate C18H32ClN3O8P2 - PubChem Chloroquine & Hydroxychloroquine supporting chemo. Volume of distribution Deranged Physiology
     
  5. Charlene Moderator

    Blurred vision - Just curious if any of you have had occasional blurred vision? I take Plaquenil but my eye exsams have been fine. No change in my eyesight. This has been going on for awhile and I keep forgetting to tell my RA Doctor.

    Should I be concerned about blurry vision taking plaquenil.
     
  6. Vicbah New Member

    Chloroquine and Hydroxychloroquine Toxicity Treatment. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ.

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