In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Chloroquine counterindications Chloroquine schizont p falciparum Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Several cases of hypopigmentation of the skin have been reported. Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy. Desorption of chloroquine and hydroxychloroquine from Sepia melanin. Initially 5 mg of melanin was saturated by equilibration with 5 mL of 1.9 mmol/L chloroquine prepared in 20 mM potassium phosphate buffer at pH 7.4 for 2 h. The samples were then centrifuged at 477 × g for 4 min and the supernatant removed. Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Chloroquine skin pigmentation Hyperpigmentation of the Skin Following Chloroquine., Chloroquine Side Effects Common, Severe, Long Term. Hydroxychloroquine rob hollandMetabolism of chloroquine Improvement of the hyperpigmentation a few months after hydroxychloroquine is stopped has been reported, but complete clearance is rare.1 Cautious use of the Q-switched ruby laser has shown promise in the treatment of nonmelanotic hyperpigmentation in limited case reports.5 Our patient’s skin discoloration partially resolved four months after switching to chloroquine. Hydroxychloroquine-related skin discoloration CMAJ. Chloroquine and hydroxychloroquine binding to melanin.. Pathological pigmentation of the skin and palate caused by.. Discolored patches on the skin are a common occurrence that most people will experience at some point in their lives. Skin discoloration can occur alongside other symptoms like itching, pain, and. Sep 15, 2009 Linoleic acid also influences skin pigmentation by stimulating epidermal turnover and increased desquamation of melanin pigment from the epidermis. Studies completed to assess the skin lightening capabilities of unsaturated fatty acids, linoleic acid or α-linoleic acid, on UV induced hyperpigmentation of brown guinea pig skin, showed an efficient lightening effect 115. Chloroquine, hydrocychloroquine, amodiaquine and quinacrine are all example of antimalarials which can cause skin pigmentation. What does the skin pigmentation look like? Usually, when you start taking antimalarials, the areas of skin pigmentation which they can cause are small and oval in shape. As you take more antimalarials, the skin pigmentation will usually develop into large patches of discolouration.