Chloroquine endocytosis inhibitor

Discussion in 'Canadian Pharmaceuticals Online' started by Chanty, 24-Feb-2020.

  1. Qwazar Moderator

    Chloroquine endocytosis inhibitor

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. An introduction to dynamin and endocytosis with a simple reference guide of inhibitors for your research. Dynamin is a key GTPase involved in various forms of endocytosis and is comprised of 3 major isoforms, all of which have four main functional domains. However, little is known about how the endocytosis of GM1 is regulated. In this study, the treatment of PC12 cells with chloroquine at low μM concentrations induced marked GM1 accumulation whereas that at high μM concentration, which is required for the inhibition of lysosomal activity, induced the GM1 disappearance.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine endocytosis inhibitor

    Search for inhibitors of endocytosis, Dynamin and endocytosis inhibitors Abcam

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  3. More specifically, we found that CQ impairs receptor-mediated endocytosis and consequently the lysosomal degradation of EGFR but it does not impair fluid phase endocytosis and endo-lysosomal routing of BSA. Therefore, CQ is not a general inhibitor of the endo-lysosomal pathway per se.

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    Amines such as phenothiazines, MDC and chloroquine inhibit clathrin-dependent endocytosis by affecting the function of clathrin and clathrin-coated vesicles Salisbury et al. 1980; Wang et al. 1993. Monensin is a monovalent ionophore that inhibits clathrin-dependent endocytosis by dissipating a proton gradient Dickson et al. 1982. Chloroquine is widely used as an antimalarial drug, anti-inflammatory agent, and it also shows antiviral activity against several viruses. Here we show that chloroquine exhibits antiviral activity against ZIKV in Vero cells, human brain microvascular endothelial cells, human neural stem cells, and mouse neurospheres. Edwardsiella tarda is a Gram-negative bacterium that can infect a broad range of hosts including humans and fish. Accumulating evidences have indicated that E. tarda is able to survive and replicate in host phagocytes. However, the pathways involved in the intracellular infection of E. tarda are unclear. In this study, we examined the entry and endocytic trafficking of E. tarda in the mouse.

  4. seosniks XenForo Moderator

    At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Shifting from Prednisone to Hydroxychloroquine Mayo Clinic. Plaquenil eye problems Mayo Clinic Connect CPPD calcium pyrophosphate deposition. Mayo Clinic Connect
  5. ra-port XenForo Moderator

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