Hydroxychloroquine weight based dosing

Discussion in 'Canadian Pharcharmy Online' started by Dron_A, 29-Feb-2020.

  1. Vers User

    Hydroxychloroquine weight based dosing


    Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid).

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    Nov 25, 2019 Alternate dosing based on body weight A total dose representing 25 mg/kg is administered in 3 days, as follows First dose 10 mg base/kg not to exceed 620 mg base orally Second dose 5 mg base/kg not to exceed 310 mg base orally 6 hours after first dose Third dose 5 mg base/kg orally 18 hours after second dose Regarding the dosing of hydroxychloroquine, we advocate the use of a weight-based dosing regimen with a cap at 400 mg per day, except in the case of renal insufficiency, when the dose should be. There were no differences in hydroxychloroquine levels when both height and ideal body weight were compared across the different blood concentrations. This suggests that we are correctly dosing patients based on actual rather than ideal body weight not exceeding a dose of 400 mg per day and indicated that dosing based on height is unnecessary.

    It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015.

    Hydroxychloroquine weight based dosing

    Hydroxychloroquine Plaquenil Dosing Calculator - MDCalc, RheumNow Hydroxychloroquine Blood Levels in SLE MedPage.

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  6. Dosing Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day.

    • Drug spotlight on hydroxychloroquine Lupus Foundation of..
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    • Plaquenil Dosage Guide -.

    An audit of 100 patients seen at any of nine Canadian rheumatology clinics during early 2016 showed that 30% of patients were not on appropriate weight-based hydroxychloroquine dosages, and 13% of patients on the drug had not received a baseline retinal assessment during their first year. Let's dive in. Melton & Thomas describe the typical safe Plaquenil dosage this way The usual dosage is two 200mg tablets per day. This is generally a "safe" dose for patients having a lean body weight of at least 135 lbs. The generally-regarded safe dosage is 6.5mg/kg/qd, thus the 135 lb. safety threshold. Apr 03, 2016 Regarding the dosing of hydroxychloroquine, we advocate the use of a weight-based dosing regimen with a cap at 400 mg per day, except in the case of renal insufficiency, when the dose should be reduced to 200 mg per day and for those on dialysis, who should take their hydroxychloroquine at 200 mg three times per week.

     
  7. Vadik Well-Known Member

    Selected from data included with permission and copyrighted by First Databank, Inc. Anyone Taking Both Plaquenil and Cellcept together. I'm using plaquenil hydroxychloroquine 200mg and. Plaquenil Oral Interactions with Other Medication
     
  8. Snoop_11 User

    Inflammatory Osteoarthritis And Plaquenil Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation when an infection is found, and these basically malfunction with inflammatory disorders.

    Hydroxychloroquine should not be used for hand osteoarthritis.
     
  9. Lover Moderator

    Cutaneous lupus erythematosus DermNet NZ Chronic cutaneous lupus erythematosus. Chronic cutaneous LE accounts for 80% of presentations with cutaneous LE. About 25% of patients with chronic cutaneous LE also have systemic LE. Discoid LE. Discoid LE is the most common form of chronic cutaneous LE.

    Systemic Lupus Erythematosus in Children and Adolescents