Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine methotrexate sulfasalazine azathioprine lefludomide Plaquenil 200mg turkey Chloroquine Phosphate, Quinine Hydrochloride, & Quinine Sulfate are anti-malarial drugs that are also often very effective for single cell ecto-parasites in fish, especially Cryptocaryon, Oodinium, Brooklynella, and occasionally Ichthyophthirius Multifilis and flukes in freshwater Chloroquine has a high affinity for tissues of the parasite and is concentrated in its cytoplasm. As a weak base, it increases the pH of the intracellular lysosome and endosome. A more acidic medium in these organelles is needed for the parasite to affect mammalian cells. As a result, chloroquine inhibits growth and development of parasites. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria. Preparation of chloroquine Chloroquine Aralen - Side Effects, Dosage, Interactions., Chloroquine - an overview ScienceDirect Topics Plaquenil and antidepressantsHow effective is plaquenil for scarring alopeciaHydroxychloroquine 200 mg used for Chloroquine phosphate is used occasionally to decrease the symptoms of rheumatoid arthritis and to treat systemic and discoid lupus erythematosus, scleroderma, pemphigus, lichen planus, polymyositis, sarcoidosis, and porphyria cutanea tarda. Talk to your doctor about the possible risks of using this drug for your condition. Chloroquine MedlinePlus Drug Information. Aralen Chloroquine Uses, Dosage, Side Effects.. Design and Synthesis of Novel Chloroquine-based Antimalarials. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine’s spectrum of activity includes the asexual erythrocytic forms of Plasmodium malariae, P.ovale, P. vivax, many strains of P. falciparum, and Entamoeba histolytica. Pharmacokinetics Absorption Absorbed readily and almost completely. Distribution 55% bound to plasma proteins. Concentrated in erythrocytes, liver, spleen, kidneys. The aim of the study was to investigate the effects of dietary combination of Nigella sativa seed and oil extracts with chloroquine CQ, and how these combinations enhance CQ efficacy in mice infected with Plasmodium berghei and their survival rates. Chloroquine.