The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Hydroxychloroquine remission rheumatoid arthritis Hydroxychloroquine retina This has important policy implications given the difference in cost between these treatments. Methotrexate combined with adalimumab, certolizumab, etanercept, or infliximab had a statistically significant benefit for inhibiting joint damage compared with oral methotrexate, but the effect was small and observed only in methotrexate naive patients. Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Difference between hydroxychloroquine and methotrexate Methotrexate and plaquenil -, Treatment of Rheumatoid Arthritis with Methotrexate Alone. Chloroquine phosphate suspension Between groups per-protocol analysis after intervention Mean SD LPPAI in methotrexate group at baseline, 4.63 1.83, was significantly higher than that in hydroxychloroquine group, 3.46 0.94, P = 0.04. reveals LPPAI difference between the two groups at Clinical efficacy and safety of methotrexate versus.. Methotrexate vs plaquenil side effects long term and short.. Compare Plaquenil vs Chloroquine -. OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. After an inadequate response to methotrexate, several treatments were statistically superior to oral methotrexate for ACR50 response triple therapy, methotrexate plus hydroxychloroquine, methotrexate plus leflunomide, methotrexate plus intramuscular gold, methotrexate plus most biologics, and methotrexate plus tofacitinib. Compare Chloroquine vs Hydroxychloroquine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Chloroquine rated 10.0/10 vs Hydroxychloroquine rated 6.7/10 in overall patient satisfaction.