Additionally, another exception occurred while executing the custom error page for the first exception. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Plaquenil immunoglobulin receptor Is there a drug interaction between inruprofen and plaquenil Selective thinning of the perifoveal inner retina as an early sign of hydroxychloroquine retinal toxicity. Skip to main content. Thank you for visiting. My last retina scan shows some thinning of the retina so I am being scheduled with a specialist for further testing and I have been told there is a good possibility I will have to stop taking Plaquenil. I know my sight is most important but it makes me nervous that I may have to change medications. Plaquenil has been a miracle drug for me. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Retinal thinning in plaquenil toxicity Retinal Physician - Hydroxychloroquine Maculopathy An., Has anyone had retinal damage from Plaquenil? - Lupus - Inspire Chloroquine sulphate 200mg side effectsHydroxychloroquine fda approvalDiscontinuing plaquenil Aug 06, 2014 Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Multimodal Imaging in Plaquenil Toxicity. The Risk of Retinal Toxicity with Plaquenil - Sjogren's. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Sep 15, 2014 Retinal toxicity is a very rare side effect of the hydroxychloroquine therapy, but when it has occurred, vision loss may be permanent and may progress even years after the cessation of medication. Patients would be examined every 3 months, then annually, until they are stabled. Ocular findings of HCQ retinal toxicity as detected by various screening modalities. A female patient was diagnosed with HCQ retinal toxicity at the age of 53 years, having taken HCQ for 12 years at 400 mg/day. She was not obese and had no additional risk factors for toxicity. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative.