Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Hydroxychloroquine and sulfasalazine Hydroxychloroquine sulfate rash Antimalarial drugs hydroxychloroquine Chloroquine resistant malaria A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine CQ was introduced in 1953, followed by HCQ in 1955, but over the years HCQ has superseded the use of CQ because of its better ocular safety profile. The adverse effects of HCQ have also been well documented and include neuromyotoxicity, cardiotoxicity and ocular toxicity. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine keratopathy Factors associated with chloroquine-induced retinopathy in., Chloroquine Oral Uses, Side Effects, Interactions, Pictures. Hydroxychloroquine do not crush plaquenil Manifestation of these corneal deposits is not related to duration, dose, or vision loss and is completely reversible upon discontinuation of the medication. Chloroquine has been associated with keratopathy more than hydroxychloroquine. Older studies have shown a decrease in corneal sensation in approximately 50% of patients taking chloroquine. Chloroquine and Hydroxychloroquine Toxicity Clinical.. Hydroxychloroquine-related retinal toxicity Rheumatology.. Chloroquine, Reactions Weekly 10.1007/s40278-013-4409-7.. Mar 15, 2019 Manifestation of these corneal deposits is not related to duration, dose, or vision loss and is completely reversible upon discontinuation of the medication. Chloroquine has been associated with keratopathy more than hydroxychloroquine. Older studies have shown a decrease in corneal sensation in approximately 50% of patients taking chloroquine. Chloroquine and its congeners can cause two typical adverse effects in the eyes keratopathy and retinopathy. Both of these effects are associated with the administration of the drugs over long periods of time. Chloroquine-induced keratopathy is limited to the corneal epithelium, where high concentrations of the drug are usually used. Corneal verticillata, or vortex keratopathy, manifests as a whorl-like pattern of golden brown or gray deposits in the inferior interpalpebal portion of the cornea in a clockwise fashion Fig 12-15. A variety of medications bind with the cellular lipids of the basal epithelial layer of the cornea due to their cationic, amphiphilic properties.