The most common side effect associated with its use is retinal toxicity, which may be irreversible. Therefore, it is pertinent to know the findings, risk factors, and screening tests necessary to prevent retinal damage. Benefits of plaquenil Chloroquine toxicity heart Chloroquine family Early signs visual field defects on 10-2 HVF usually paracentral, perifoveal and parafoveal thinning of the retina with loss of the inner/outer segment junction on SD-OCT, increased or decreased signal on autofluorescence, central/paracentral ERG depression on mfERG, +/- changes on Amsler grid, +/- subtle RPE changes, +/- decreased color vision A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. Feb 19, 2020 PLAQUENIL is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax. PLAQUENIL is indicated for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported. During the first five years of use, the rate of toxicity was found to be 0.7%, rising significantly to more than 1% after five to seven years of use. The prevalence of retinal toxicity has varied among different studies. Visual field changes with plaquenil Multimodal Imaging in Plaquenil Toxicity, Hydroxychloroquine Plaquenil Toxicity and. Tapering hydroxychloroquineChloroquine phosphate aquariumIs plaquenil hair loss permanentMost common side effects of hydroxychloroquine In many cases, the diagnosis of HCQ retinal toxicity was delayed when visual field tests were dismissed as “nonspecific.” Therefore, an abnormal visual field should first be repeated. If consistent changes are confirmed, one or more of the objective tests discussed below should be performed. Retinal Physician - Hydroxychloroquine Maculopathy An.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Plaquenil Side Effects on Your Eyes and Vision. Dec 04, 2014 Visual fields. The subjective component to HCQ retinopathy screening is an automated visual field testing the central 10° of vision. The earliest signs of HCQ retinopathy on a central visual field may present as a cluster of paracentral points with decreased sensitivity. These points may be only mildly depressed. Apr 20, 2011 Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. The use of 4-aminoquinolines is generally considered contraindicated in the presence of retinal or visual field changes, whether attributable to 4-aminoquinoline compounds or to any other etiology. However, in the treatment of acute attacks of malaria caused by susceptible strains of plasmodia, these agents may be considered if potential benefits are anticipated to outweigh the risks.