Keep in mind that most people with Sjogren's stay healthy and don't have serious problems. You should be able to keep doing all the things you love to do without making many changes. Can use of plaquenil have effect on vaccinations years later Plaquenil monitoring Mycophenolate and plaquenil for dermatomyositis For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Sjogren's syndrome is an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva. It also associated with rheumatic disorders such as rheumatoid arthritis, and it is rheumatoid factor positive in 90 percent of cases. Alternatives to Plaquenil. deleted_user 06/11/2012. Conditions like this are called autoimmune diseases. Sjogren's causes your immune system to go haywire and attack healthy cells instead of invading bacteria or viruses. Plaquenil for sjogren's syndrome New Sjogren's Guidelines Outline 19 Treatment Recommendations., Conquering Sjogren's Plaquenil Hydroxychloroquine in sle In some patients, the anti-rheumatic drug Plaquenil has been beneficial in decreasing pain and salivary gland swelling. Sjogren's Syndrome Foundation. MedlinePlus "Sjogren's Syndrome." What medications are used to treat Sjögren's syndrome?. Alternatives to Plaquenil DailyStrength. Hydroxychloroquine treatment for primary Sjögren's syndrome.. There are other treatments for some of the less common symptoms of Sjogren's syndrome. For instance, if you get yeast infections in your mouth, your doctor might prescribe anti-fungal medicine. If you get heartburn, your doctor may give you medicines that curb the amount of acid in your stomach. User Reviews for Plaquenil to treat Sjogren's Syndrome. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. New Treatment Guidelines for Sjo¨gren’s Disease 533 all methodology elements, including protocol worksheets, data extraction tables, and literature search terms.