Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. What is the chemical name for plaquenil Plaquenil cause anemia Plaquenil for raynaud' Sep 13, 2019 Applies to hydroxychloroquine oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. About 25% of patients receiving chloroquine or hydroxychloroquine for several years develop bluish-grey pigmentation on face, neck and sometimes lower legs and forearms Continuous long-term use may lead to blue-black patches, especially in sun-exposed areas Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. OBJECTIVE To describe the clinical features and outcome of hydroxychloroquine HCQ-induced pigmentation in patients with systemic lupus erythematosus SLE. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine pigmentation histology Hydroxychloroquine-related skin discoloration CMAJ, Drug-induced hyperpigmentation DermNet NZ Cost of plaquenil in irelandHow does plaquenil affect eyes Hydroxychloroquine-Induced Hyperpigmentation. From the Departments of *Rheumatology and †Dermatology, Walter Reed National Military Medical Center; and ‡Uniformed Services University of the Health Sciences, Bethesda, MD. No financial support was received for this study. The authors declare no conflict of interest. Hydroxychloroquine-Induced Hyperpigmentation JCR Journal.. Hydroxychloroquine-induced pigmentation in patients with.. Skin Pigmentation with Hydroxychloroquine Plaquenil — Donovan Hair Clinic. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B.