The main finding in scleroderma is thickening and tightening of the skin and inflammation and scarring of many body parts, leading to problems in the lungs, kidneys, heart, intestinal system and other areas. Twins and family members of those with scleroderma or other autoimmune connective tissue diseases, such as lupus, may have a slightly higher risk of getting scleroderma. There is still no cure for scleroderma, but effective treatments for some forms of the disease are available. Children can also develop scleroderma, but the disease is different in children than in adults. Aralen manufacturer Hydroxychloroquine side effects class Como ayuda el plaquenil es el lupus In Limited cutaneous systemic sclerosis CREST syndrome, skin thickening and tightness is typically limited to the fingers and toes. This form of scleroderma is also associated with the formation of calcified nodules under the skin, Raynaud’s phenomenon, problems with movement of the esophagus, and dilated blood vessels in the skin called. I stopped Plaquenil eons ago prior to Cytokine testing and haven't needed to get back on it. While it is a good drug, it is a good drug for what it's indicated for and CREST syndrome, lupus, Sjogrens and other auto-immune conditions will benefit from it. As a reminder it will only work if taken over the long term. Alpert MA, Pressly TA, Mukerji V, et al. Acute and long-term effects of nifedipine on pulmonary and systemic hemodynamics in patients with pulmonary hypertension associated with diffuse systemic sclerosis, the CREST syndrome and mixed connective tissue disease. A great deal of research is also underway to find better treatments for scleroderma and, hopefully, someday a cure. Although the underlying cause is unknown, promising research is shedding light on the relationship between the immune system and scleroderma. Hydroxychloroquine for crest syndrome Plaquenil--used To Treat Crest? - Sclero Forums MAIN., Plaquenil/ hydroxychloroquine Phoenix Rising ME / CFS Forums Plaquenil oral lichen planusHydroxychloroquine sulfate eye side effectsPlaquenil oct flying saucerDoes plaquenil show up in the blood But the clear link between tryptophan and eosinophilia myalgia syndrome and the scleroderma-like disease associated with contaminated rapeseed oil ingestion raise the possibility that exposure to something in the environment could trigger scleroderma. Symptoms. The symptoms of scleroderma vary from person to person and can include Scleroderma Guide Causes, Symptoms and Treatment Options. Prognosis and treatment of mixed connective tissue disease.. Methotrexate in Patients With Scleroderma/CREST Syndrome. The cause isn’t known, but CREST syndrome limited scleroderma is believed to be an autoimmune disorder, in which your immune system turns against your body. The immune system in people with CREST syndrome appears to stimulate cells called fibroblasts to produce excess amounts of collagen, a key component of connective tissue. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for.