Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Hydroxychloroquine sulfate melasma Plaquenil steady state Chloroquine is known to be a non-specific antiviral agent, but its effect on the Zika virus replication has not been evaluated yet. This is the first report of inhibitory effects of chloroquine on ZIKV replication, which, given the ongoing epidemics, may become interesting both for the scientific knowledge of the virus and for the clinical. Chloroquine Chl is an anti-rheumatic drug that is widely used in the treatment of rheumatoid arthritis RA. It seems that T cells are important in the pathogenesis of RA, but it is not known whether Chl acts via inhibition of T cell function. We here. Chloroquine raises the lysosomal pH and inhibits lysosome-autophagosome fusion. Chloroquine also has been used as a non-steroidal anti-inflammatory drug to treat rheumatoid arthritis, lupus erythematosus, and multiple sclerosis 20–22. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine inhibits Chloroquine inhibits human CD4 + T-cell activation by AP-1 signaling., Chloroquine inhibits T cell proliferation by interfering with IL-2. Chloroquine weak basePlaquenil lupus en espanolPlaquenil safe to take Nov 29, 2016 Chloroquine is known to be a non-specific antiviral agent, but its effect on the Zika virus replication has not been evaluated yet. This is the first report of inhibitory effects of chloroquine on ZIKV replication, which, given the ongoing epidemics, may become interesting both for the scientific knowledge of the virus and for the clinical. Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika.. Chloroquine Inhibits HMGB1 Inflammatory Signaling and Protects Mice.. Chloroquine - Wikipedia. Chloroquine diphosphate CQ could inhibit cell growth, elicit cell apoptosis, and induce necrosis in A549 cells at different concentrations. Moreover, the results suggested the involvement of PC-PLC in cell growth inhibition by CQ at lower concentrations. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. It increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. In suppressive treatment, chloroquine inhibits the erythrocytic stage of development of plasmodia. Chloroquine, a widely used anti‐malarial and anti‐rheumatoid agent, has been reported to induce apoptotic and non‐apoptotic cell death. Accumulating evidence now suggests that chloroquine can sensitize cancer cells to cell death and augment chemotherapy‐induced apoptosis by inhibiting autophagy.