Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hydroxychloroquine with all of your drugs and health problems. Antimalarials hydroxychloroquine Chloroquin urine color Plaquenil is used to inhibit disease progression - most of us are started on it immediately and need to remain on it long-term. Takes 2-3 months to build up in your system. Generally a rheumy will then choose one of these three; Imuran, Cellcept, or MTX to inhibit the over-active autoimmune system that is Lupus. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Side effects associated with Plaquenil are placed in three categories common, less common, and rare. If you have any of the following effects and they persist or worsen, notify your doctor or pharmacist promptly. For all uses of hydroxychloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Plaquenil and imuran heat and sun side effects Anyone on methotrexate and imuran? lupus, Hydroxychloroquine Side Effects - Plaquenil weight loss or gain Azathioprine Imuran® has some activity in rheumatoid arthritis but may take 8-12 weeks to see an effect. It is a purine analog that can cause bone marrow suppression and lowering of blood cell counts white blood cells, red blood cells, and platelets particularly in patients with renal insufficiency or when used concomitantly with. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Imuran or methotrexate - Lupus - MedHelp. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Get medical help right away if you have any of these side effects clumsiness, loss of coordination/balance, weakness, sudden change in your thinking such as confusion, difficulty concentrating, memory loss, difficulty talking/walking, seizure, vision changes.