Some drugs fight inflammation and ease pain, while others help slow disease progression. If there's any comfort in having rheumatoid arthritis these days, it’s that there's a growing number of drugs to deal with its symptoms. Not only can some medications help manage the inflammation, pain, and symptoms of rheumatoid arthritis, but they can stop or slow the progression of the disease, too. Hydroxychloroquine and sunlight eyes Can you breastfeed while on plaquenil In combination with methotrexate for active disease in adult patients when the response to disease-modifying anti-rheumatic drugs DMARDs including methotrexate has been inadequate, or the treatment of severe, active and progressive disease in adults not previously treated with methotrexate or other DMARDs. If a patient is resistant to initial DMARD treatment with an agent such as methotrexate, combination DMARD treatment may be used, adding one or more conventional DMARDs leflunomide, hydroxychloroquine, sulfasalazine or a newer biologic treatment to methotrexate. Methotrexate is often used in combination with other DMARDs. Conventional DMARDs that have been paired with methotrexate include sulfasalazine, hydroxychloroquine, cyclosporine, leflunomide and azathioprine. Treatment guidelines from the American College of Rheumatology (ACR) state that early aggressive treatment is the best way to prevent irreversible joint damage and to maintain quality of life for people with rheumatoid arthritis. Traditionally, rheumatoid arthritis treatments have included a combination of DMARDs, or disease modifying anti-rheumatic drugs, that now include different forms of biologics and two other classes of medications: non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. Dmards plaquenil methotrexate Disease-modifying Antirheumatic Drugs DMARDs. Patient., Traditional Disease-Modifying Anti-Rheumatic Drugs DMARDs Oral plaquenil eye examStopped taking plaquenilEffects of plaquenil on visionPlaquenil lyme cysts Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate vs Plaquenil Comparison -. DMARDs Arthritis Foundation. Reclassifying DMARDs Targeted Versus Conventional Therapies. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 Methotrexate Methotrexate may be sold under the brand names Trexall™, Otrexup ®, Rheumatrex ®, and Rasuvo ®. In addition to being used as a treatment for PsA, methotrexate has been used for decades to treat psoriasis. It helps with pain and swelling, and as a DMARD, it can help slow the progression of the disease. Commonly used oral DMARDs include methotrexate, sulfasalazine, hydroxychloroquine, low-dose prednisone and a newer agent, leflunomide. Other less commonly used DMARDs include azathioprine, cyclosporin and sodium aurothiomalate intramuscular gold. Biological DMARDS, tumour necrosis factor TNF inhibitors, are discussed below.